Virus spike – Communicable Diseases Research

Priming conditions shape breadth of neutralizing antibody responses to sarbecoviruses

Article

Published on 2022-10-212022-11-15
Journal: Nature Communications
[Category] COVID19(2023년), SARS, 변종, 진단,

SARS-CoV-2 Spike mutations modify the interaction between virus Spike and human ACE2 receptors

SARS-CoV-2 스파이크 돌연변이는 바이러스 스파이크와 인간 ACE2 수용체 간의 상호 작용을 수정합니다

Article

Published on 2022-09-102022-09-11
Journal: Biochemical and Biophysical Research Communication
[Category] COVID19(2023년), SARS, 변종,

In Silico and In Vitro Studies of Alchemilla viridiflora Rothm-Polyphenols’ Potential for Inhibition of SARS-CoV-2 Internalization

Alchemilla viridiflora Rothm-Polyphenols의 SARS-CoV-2 내재화 억제 가능성에 대한 실리코 및 체외 연구

Article

Published on 2022-08-142022-09-11
Journal: Molecules
[Category] SARS, 변종,

[키워드] ACE2 Alchemilla viridiflora Rothm. angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Antiviral agents binding binding energy binding interaction Compound computational studies Computational study Contact COVID-19 COVID-19 pandemic dose doses E484K effective Effectiveness exhibited flavonoid G476S glycoprotein Health higher affinity highest in silico in vitro inhibited inhibition internalization investigated K417N methanol molecular docking studies Molecular docking study Mutation N439K N501Y neuropilin Neuropilin-1 NRP1 outbreak plants polyphenols Potential Prevent quercetin receptor receptors resulting SARS-CoV-2 SARS-CoV-2 strain selected significantly spike glycoprotein spike glycoprotein. tested V483A virus virus infection Virus spike wild strain
[DOI] 10.3390/molecules27165174 PMC 바로가기 [Article Type] Article

SARS-CoV-2 Variants of Concern and Variants of Interest Receptor Binding Domain Mutations and Virus Infectivity

Immunology

Published on 2022-01-272022-11-01
Journal: Frontiers in Immunology
[Category] COVID-19, SARS,

[키워드] ACE2 ACE2 binding acute respiratory syndrome Adenovirus Affect antibody antigenic site approved bamlanivimab binding Breakthrough infection Cell concern coronavirus death effective enzyme full-length Host Immunity immunize infected patient infected patients Infection infections Infectivity interest monoclonal antibody mRNA vaccine Mutation neutralization neutralizing antibody pandemic protein structure model RBD RBD mutation receptor Receptor binding domain reported SARS-CoV-2 SARS-CoV-2 variant serum antibody the RBD therapeutic treat vaccinated individual vaccinated individuals Vaccine Vaccine-induced immunity variants variants of interest virus Virus spike virus spike protein VoC
[DOI] 10.3389/fimmu.2022.825256 PMC 바로가기 [Article Type] Immunology

Computational design of a neutralizing antibody with picomolar binding affinity for all concerning SARS-CoV-2 variants

Antibody response to COVID-19 vaccine: A point of view that can help to optimize dose distribution

COVID-19 백신에 대한 항체 반응: 용량 분포를 최적화하는 데 도움이 될 수 있는 관점

Observational Study

Published on 2022-01-012022-09-12
Journal: International immunopharmacology
[Category] MERS, SARS, 임상, 진단,

Evaluation of Three Quantitative Anti-SARS-CoV-2 Antibody Immunoassays

3가지 정량적 항-SARS-CoV-2 항체 면역분석법의 평가

Research Article

Published on 2021-12-222022-09-10
Journal: Microbiology Spectrum
[Category] SARS, 진단, 치료기술,

[키워드] (Abbott Abbott acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 anti-SARS-CoV-2 anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody antibody Antibody titer Antibody titers Antigen binding antibodies caused Chemiluminescent assay convalescent plasma coronavirus correlated correlation COVID Critical detect determine DiaSorin ELISA evaluated herd immunity house identify IgG Immunity immunization immunoassay Infection International international standard less LIAISON Live virus monoclonal antibodies Neutralization assay Neutralizing antibodies Neutralizing antibody titer neutralizing antibody titers NIBSC not correlated pandemic performed Postinfection proportional bias Protective respiratory SARS-CoV-2 SARS-CoV-2 IgG SARS-CoV-2 strain sensitivities sensitivity sera serological Serological assay serological assays serological result serological results severe acute respiratory syndrome Coronavirus significantly Specificities specificity spike tested the immunoassay the SARS-CoV-2 Treatment vaccination virus neutralization assay virus neutralization assays Virus spike WHO
[DOI] 10.1128/spectrum.01376-21 PMC 바로가기 [Article Type] Research Article

Reduced neutralisation of the Delta (B.1.617.2) SARS-CoV-2 variant of concern following vaccination

델타의 중화 감소 (B.1.617.2) 예방 접종 후 SARS-COV-2 우려 변형

Research Article

Published on 2021-12-022022-08-13
Journal: PLoS Pathogens
[Category] Biochemistry, SARS, 변종, 진단,

[키워드] (Beta accumulation African antibody Antibody titre antigenic antigenic drift antigenic profiles assessment Astra Zeneca Author B.1.351 B.1.617.1 B.1.617.2 bat bats Beta BNT162b2 BNT162b2 vaccines Booster vaccine booster vaccines ChAdOx1 changes in collected COVID-19 COVID19 death decrease decreases Delta delta variant dose effective Effectiveness Efficacy elicited evade expressed facilitate fold Fold changes glycoprotein groups hospitalisation Human human cell human cells humans Immunity India indicated individual Infection Lineage magnitude Mutation neutralisation neutralise Neutralising Antibodies neutralising antibody titres of BNT162b2 Pfizer Pfizer/BioNTech Prevent profile protective immune response pseudoviruses recipient recipients reduced reduction reduction in reductions reductions in required risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 virus sensitivity sera Severe infection shape significantly higher South South Africa spike glycoprotein spike glycoproteins Spike protein subsequent the spike protein titre vaccinated individuals vaccination Vaccine vaccine efficacy Vaccines variant variant B.1.617.2 variants variants of concern Viral viral variant Viral variants virus Virus spike VOCs while with infection with infections Wuhan Wuhan, China
[DOI] 10.1371/journal.ppat.1010022 PMC 바로가기 [Article Type] Research Article

Immune Response of Neonates Born to Mothers Infected With SARS-CoV-2

SARS-CoV-2에 감염된 산모에게서 태어난 신생아의 면역 반응

Observational Study

Published on 2021-11-032022-09-10
Journal: JAMA Network Open
[Category] MERS, SARS, 임상, 진단, 치료기술,

[키워드] 48 hour 48 hours age antibody antibody production arbitrary unit association Birth breastmilk children Clinical outcome cohort study enrolled enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay evaluated explain exposure exposure to finding Follow-up gestational age IgA IgA antibodies IgA antibody IgG antibodies IgM antibodies IgM antibody immune complex Immune complexes immune response immune responses immune system Importance in utero Infant Infants infected with SARS-CoV-2 Infection infection with SARS-CoV-2 information investigated IQR Italy life male Maternal maternal age measure mother mucosal mucosal immune Neonatal Neonate Newborn objective occurred offspring participant parturition passive immunity Point positive Pregnancy pregnant women prospective cohort study PROTECT provided Receptor binding Receptor binding domain Relevance response Result Rome Saliva salivary SARS-CoV-2 SARS-CoV-2 IgG SARS-COV-2 infection SARS-CoV-2 spike secretory IgA serum setting significantly higher significantly increased specific antibodies specific antibody specific IgG antibodies spike-specific antibodies Spike-specific antibody spike-specific IgG stimulate systemic immune response systemic immune responses tested transfer Transmission Umberto vertical transmission vertical virus transmission virus Virus spike virus transmission
[DOI] 10.1001/jamanetworkopen.2021.32563 PMC 바로가기 [Article Type] Observational Study

Identifying key determinants and dynamics of SARS-CoV-2/ACE2 tight interaction

SARS-CoV-2/ACE2 긴밀한 상호 작용의 주요 결정 요인 및 역학 식별

Research Article

Published on 2021-09-282022-09-12
Journal: PLoS ONE
[Category] SARS, 진단,